Micky van de Ven Brace Ends Everton's Unbeaten Streak at New Home Ground
The Dutch defender emerged as the first defender to score two goals in a Premier League match for Tottenham since Jan Vertonghen in spring 2013.
Match summary
The Spurs defender nods into the net twice in opening period
Everton's Jake O'Brien has goal disallowed after VAR review
Pape Matar Sarr scores third in dying moments
The defeat is the Merseyside club's initial at Hill Dickinson Stadium
The Tottenham defender scored on two occasions as Tottenham extended their winning streak in away games in the top division and handed the Toffees their initial loss at Hill Dickinson Stadium.
The Toffees were undefeated in their last five matches at their recently opened stadium at the dockside location, having departed their historic home behind after more than a century at the end of the previous campaign.
But Tottenham's leader Van de Ven struck on two occasions from corners in the opening 45 minutes to put their strong form at jeopardy, and they were failed to mount a comeback before the midfielder - assisted by ex-Everton forward the Brazilian - headed home a third to seal the victory.
Jake O'Brien thought he had levelled the scores a short while after Van de Ven's opener, glancing a powerful header past the Spurs keeper from an set-piece.
The Portuguese striker, meanwhile, failed to convert a handful of opportunities, while Vicario made a succession of fine saves to ensure the London club went five matches on the road without defeat in the English top flight.
But the VAR stepped in, advising Craig Pawson to review the goal on the pitchside monitor and the referee decided that Jack Grealish and Iliman Ndiaye were in an illegal position and had interfered with the Spurs keeper.
The win moves the manager's team up to third in the Premier League, a handful of points off north London rivals and leaders Arsenal.
The Merseyside club remain in 14th position and sit half a dozen points clear of the drop zone.
Tottenham analysis: Van de Ven fulfils duties at both ends of pitch
Following a drab midweek display in the Champions League against Monaco, where they managed a mere attempts on goal, Frank chose the French striker up front instead of ex-Everton forward Richarlison.
The summer signing was unable to influence the game before being substituted for the substitute after an hour on the field, but it emerged he proved unnecessary in the final outcome.
Centre-back the Dutchman converted into an attacking force to be feared.
Tottenham's opening strike came from a cleverly executed set-piece play, with the midfielder directing the ball back across the face of goal for an unmarked the defender to score.
And the captain - filling in as captain in Cristian Romero's absence - added his next goal in first-half stoppage time as he rose above the England keeper to nod in.
The Dutchman was equally outstanding in defence, partnering effectively with his defensive colleague as the duo dealt excellently with the numerous deliveries thrown their way by Everton.
Everton analysis: Toffees lacking striker's instinct
The club's new home had been a happy hunting ground, but it appears the novelty may have faded slightly and fans flocked to the exits after the midfielder's final goal for Spurs.
The end in the team's unbeaten home run won't be a massive concern for David Moyes, but their striker situation will be.
Beto and Thierno Barry - the Everton's two recognised strikers - had scored just one league goal combined before Sunday's outing.
And they were unable to add to that miserable record on a wet and gloomy evening on in Liverpool.
The striker's form was epitomized when he opted to bicycle-kick a golden opportunity from near the goal, despite having space and time to readjust for a more conventional shot that would have challenged Vicario.
The substitute, as well, failed to make an impact after replacing the starter in the second half.
It was not for a shortage of opportunity. Most of Everton's attacks came through the winger and the forward, who relentlessly delivered dangerous balls into the Spurs penalty area.
Upcoming fixtures for both teams?
Everton: The team head to the Stadium of Light in the top flight on early November at 20:00 GMT.
Tottenham: The London club travel to Newcastle's ground on Wednesday, 29 October for their next round League Cup tie against Newcastle.